hrp0095p1-209 | Adrenals and HPA Axis | ESPE2022

Systematic review of cortisol levels during acute illnesses in children and young people not known to have glucocorticoid deficiency

Banerjee Indraneel , Patel Leena , Fullwood Catherine , Hird Beverly , Chawla Meghna , Tetlow Lesley , Rezai Mohammad

Importance: Current practice of doubling or trebling the basal glucocorticoid (GC) replacement dose during acute illnesses in children and young people (CYP) with GC deficiency is extrapolated from research in adults and not based on robust evidence. Endogenous cortisol levels during acute illnesses in CYP without GC deficiency can provide insight for optimal GC stress dosing for CYP with GC deficiency.Objective: To summ...